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Malaria

Medical need

Half the world’s population are at risk of malaria, a life-threatening disease caused by parasites. About 250 million cases are reported each year, resulting in nearly one million deaths.

Over the past century, inappropriate use of anti-malarials has contributed to drug-resistant strains, thereby increasing the prevalence of the disease.

Source: http://www.who.int/mediacentre/factsheets/fs094/en/index.html

Background and rationale for a multi-stage genetic malaria vaccine

The complex life cycle and antigen variability of the parasite that causes malaria have traditionally presented challenges in the creation of a vaccine. We believe that our potent adenovirus vectors could provide a new answer.

At Okairos, we are collaborating with the University of Oxford on four malaria antigens in various stages of preclinical and clinical development. Our long-term programme is the development of a multigen vaccine targeting the various stages of the parasite lifecycle.